Even though blood tests are quite accurate, they are falsely positive 1-3% of the time (i.e., being positive without the person having celiac) and, although less commonly, falsely negative 1-2%…
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“False positive”
Screening for celiac disease
…the blood tests are quite accurate, they may occasionally produce false positive results (when someone who does not have celiac disease receives a positive test result) or, less commonly, false…
FAQ: Could you have positive blood work and a positive biopsy and not have celiac disease?
Positive blood work (meaning tTG or EMA) and a biopsy consistent with celiac disease are rarely due to other causes. However, Crohn’s disease is known to be often associated with…
FAQ: Is it possible to have a positive blood test, but not have celiac disease?
Yes, blood work can be falsely positive, as can any test in medicine, especially at low titers. However, it may be that the biopsy was done or read incorrectly or…
FAQ: If someone has positive blood test, positive biopsy, but no response to a gluten-free diet would that mean something other than celiac disease?
It could mean there are other conditions concomitantly causing the symptoms, and they should be thoroughly investigated. If none are found, then the possibility of “refractory sprue” (refractory celiac disease)…
FAQ: What does a “weak positive” blood test result for celiac disease mean?
Each lab defines “weak positive” differently. Unfortunately, diagnosis is not always a clear cut positive or negative. If you receive a weak positive, please work with your medical professional to…
FAQ: In follow-up blood testing, why would tTG be negative and DGP be positive?
If the slightly positive test is the DGP-IgA, you can disregard this value, as it can be misleading. If the DGP-IgG is positive it probably means you’re ingesting small amounts…
FAQ: If my positive antibody test suggests I may have celiac disease, how do I find out for sure?
…the genes predisposing to celiac must be present, tTG has to be very elevated and EMA blood test must be clearly positive. Also, there must be a positive response to…
FAQ: Is it possible to have a negative blood test, but a positive biopsy?
…IgA deficiency is a reason why you might have a negative blood test, but a positive biopsy. Further medical evaluation is important for anyone still experiencing symptoms in order to…
FAQ: If you have a positive antibody test and an inconclusive biopsy (it only shows inflammation, but no blunting), what’s the next approach?
A patient and doctor must consider the patient’s clinical history, what antibodies were positive and to what extent, and what, exactly, the biopsy showed to determine what’s next.